Nicotine pharmacokinetics hais txog yuav ua li cas lub cev ua nicotine tom qab nws noj. Ntawm no yog ib qho kev sib cais:
1. Kev nqus tau: Nicotine tuaj yeem nqus tau los ntawm ntau txoj hauv kev, suav nrog kev nqus pa (xws li kev haus luam yeeb), kev nqus ntawm qhov ncauj (yuav haus luam yeeb lossis cov pos hniav nicotine), lossis los ntawm daim tawv nqaij (xws li daim ntaub nplaum). Inhalation muab qhov nqus sai tshaj plaws vim tias nicotine nkag mus rau hauv cov hlab ntshav los ntawm lub ntsws. Qhov ncauj thiab dermal nqus tau qeeb dua, tab sis tseem muaj txiaj ntsig zoo ntawm kev nqus.
2. Kev faib tawm: Thaum nicotine nqus tau lawm, nws tau nrawm nrawm thoob plaws lub cev los ntawm cov ntshav. Nws yooj yim hla cov ntshav-hlwb barrier thiab ncav cuag lub hlwb hauv vib nas this. Nicotine kuj faib rau lwm cov ntaub so ntswg, nrog rau cov leeg nqaij, lub plawv, thiab cov nqaij rog.
3. Metabolism: Lub siab feem ntau metabolizes nicotine. Lub luag haujlwm tseem ceeb ntawm nicotine metabolism yog cytochrome P450 2A6 (CYP2A6). Nicotine yog metabolized rau hauv ntau lub tebchaw, suav nrog nws cov metabolite, cotinine. Cotinine yog ntxiv metabolized rau hauv lwm cov tebchaw xws li trans-3'-hydroxycotinine thiab nicotine N'-oxide.
4. Kev tshem tawm: Nicotine thiab nws cov metabolites raug tshem tawm los ntawm cov zis. Kev tshem tawm ib nrab-lub neej ntawm nicotine nyob ntawm cov yam ntxwv xws li cov metabolism hauv tus kheej, zaus ntawm kev haus luam yeeb, thiab txoj kev tswj hwm. Qhov nruab nrab, nicotine muaj ib nrab lub neej ntawm li 2 teev, txhais tau tias ib nrab ntawm cov nicotine noj yuav raug tshem tawm ntawm lub cev thaum lub sijhawm no.
5. Cov yam ntxwv cuam tshuam rau cov tshuaj pharmacokinetics: Ntau yam tuaj yeem cuam tshuam rau cov tshuaj pharmacokinetics ntawm nicotine, suav nrog cov noob caj noob ces, lub siab ua haujlwm, hnub nyoog, poj niam txiv neej, thiab kev siv lwm yam tshuaj (xws li tshuaj lossis cawv). Tsis tas li ntawd, cov neeg haus luam yeeb ib txwm muaj peev xwm tsim kev ua siab ntev rau nicotine, cuam tshuam rau nws cov metabolism thiab tshem tawm tus nqi dhau sijhawm.
Nkag siab txog nicotine pharmacokinetics yog qhov tseem ceeb los ntsuas nws cov teebmeem ntawm lub cev thiab tsim kom muaj kev haus luam yeeb zoo thiab cov tswv yim kho nicotine hloov pauv.